Drug interactions
Cyproheptadine + Methylenedioxymethamphetamine
Severity: Minor
Cyproheptadine and Methylenedioxymethamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyproheptadine is sedating and blocks 5-HT2 receptors, whereas MDMA is a stimulant that releases serotonin. Their effects may partly oppose each other, and cyproheptadine may blunt MDMA's serotonergic effects, but the outcome is unpredictable.
What this interaction means in plain words
Cyproheptadine and Methylenedioxymethamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CNS effects and 5-HT2 receptor antagonism; interaction not well characterized.
What to do
Counsel against MDMA use. If exposure occurs, monitor for serotonin toxicity and hyperthermia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Frequently asked questions
Can I take Cyproheptadine with Methylenedioxymethamphetamine?
MediHelp rates the interaction as minor. Cyproheptadine and Methylenedioxymethamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyproheptadine is sedating and blocks 5-HT2 receptors, whereas MDMA is a stimulant that releases serotonin. Their effects may partly oppose each other, and cyproheptadine may blunt MDMA's serotonergic effects, but the outcome is unpredictable.
How serious is the interaction between Cyproheptadine and Methylenedioxymethamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel against MDMA use. If exposure occurs, monitor for serotonin toxicity and hyperthermia.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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