Drug interactions
Cyproheptadine + Metoclopramide intranasal
Severity: Moderate
Cyproheptadine and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide is a prokinetic D2 antagonist, and cyproheptadine has anticholinergic activity that opposes its gastrointestinal prokinetic effect. Both can cause drowsiness. Cyproheptadine's antiserotonergic effect may also oppose metoclopramide's 5-HT4-mediated action.
What this interaction means in plain words
Cyproheptadine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism through anticholinergic and anti-serotonergic effects of cyproheptadine, with additive sedation.
What to do
Monitor for reduced gastric emptying benefit and increased drowsiness. Consider a non-anticholinergic antihistamine if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Frequently asked questions
Can I take Cyproheptadine with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Cyproheptadine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide is a prokinetic D2 antagonist, and cyproheptadine has anticholinergic activity that opposes its gastrointestinal prokinetic effect. Both can cause drowsiness. Cyproheptadine's antiserotonergic effect may also oppose metoclopramide's 5-HT4-mediated action.
How serious is the interaction between Cyproheptadine and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced gastric emptying benefit and increased drowsiness. Consider a non-anticholinergic antihistamine if appropriate.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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