Drug interactions
Cyproheptadine + Mipomersen
Severity: Minor
Cyproheptadine and Mipomersen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen can raise liver enzymes and cause hepatic fat accumulation. Cyproheptadine has only rare hepatic reports, so any additive hepatotoxicity is largely theoretical.
What this interaction means in plain words
Cyproheptadine and Mipomersen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive hepatotoxicity; no established mechanism.
What to do
Follow the standard liver enzyme monitoring required for mipomersen. Investigate promptly if transaminases rise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Frequently asked questions
Can I take Cyproheptadine with Mipomersen?
MediHelp rates the interaction as minor. Cyproheptadine and Mipomersen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mipomersen can raise liver enzymes and cause hepatic fat accumulation. Cyproheptadine has only rare hepatic reports, so any additive hepatotoxicity is largely theoretical.
How serious is the interaction between Cyproheptadine and Mipomersen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow the standard liver enzyme monitoring required for mipomersen. Investigate promptly if transaminases rise.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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