Drug interactions
Cyproheptadine + Olanzapine
Severity: Moderate
Cyproheptadine and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sedating and have anticholinergic properties, so combined use can increase drowsiness, orthostatic hypotension and anticholinergic effects. Appetite and weight gain may also be additive.
What this interaction means in plain words
Cyproheptadine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Olanzapine belongs to Central Nervous System.
Why it happens
Additive H1 antagonism, antimuscarinic effects and CNS depression.
What to do
Monitor sedation, blood pressure and anticholinergic symptoms, and counsel on driving. Adjust doses if impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Olanzapine
Frequently asked questions
Can I take Cyproheptadine with Olanzapine?
MediHelp rates the interaction as moderate. Cyproheptadine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sedating and have anticholinergic properties, so combined use can increase drowsiness, orthostatic hypotension and anticholinergic effects. Appetite and weight gain may also be additive.
How serious is the interaction between Cyproheptadine and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and anticholinergic symptoms, and counsel on driving. Adjust doses if impairment occurs.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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