Drug interactions
Cyproheptadine + Olopatadine intranasal
Severity: Moderate
Cyproheptadine and Olopatadine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyproheptadine is a markedly sedating first-generation antihistamine, and intranasal olopatadine can also cause somnolence. Used together they may add to drowsiness and impair psychomotor performance, including driving ability.
What this interaction means in plain words
Cyproheptadine and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central H1-receptor antagonism and CNS depression.
What to do
Counsel the patient to avoid driving and hazardous tasks until the combined effect is known. Consider a non-sedating alternative for allergic symptoms if drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Frequently asked questions
Can I take Cyproheptadine with Olopatadine intranasal?
MediHelp rates the interaction as moderate. Cyproheptadine and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyproheptadine is a markedly sedating first-generation antihistamine, and intranasal olopatadine can also cause somnolence. Used together they may add to drowsiness and impair psychomotor performance, including driving ability.
How serious is the interaction between Cyproheptadine and Olopatadine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to avoid driving and hazardous tasks until the combined effect is known. Consider a non-sedating alternative for allergic symptoms if drowsiness occurs.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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