Drug interactions
Cyproheptadine + Passion flower
Severity: Moderate
Cyproheptadine and Passion flower: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Passion flower has mild sedative properties that may add to the drowsiness caused by cyproheptadine. The combination could impair alertness and psychomotor performance.
What this interaction means in plain words
Cyproheptadine and Passion flower can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects, probably through GABAergic activity of passion flower.
What to do
Advise patients to watch for excess drowsiness and avoid driving until response is known. Consider stopping the herbal product if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Frequently asked questions
Can I take Cyproheptadine with Passion flower?
MediHelp rates the interaction as moderate. Cyproheptadine and Passion flower can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Passion flower has mild sedative properties that may add to the drowsiness caused by cyproheptadine. The combination could impair alertness and psychomotor performance.
How serious is the interaction between Cyproheptadine and Passion flower?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to watch for excess drowsiness and avoid driving until response is known. Consider stopping the herbal product if sedation is troublesome.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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