Drug interactions
Cyproheptadine + Pimozide
Severity: Moderate
Cyproheptadine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation and have anticholinergic activity, so combined use can increase drowsiness and cognitive slowing. Pimozide also carries QT-prolongation risk, so any additional adverse effects such as sedation or confusion complicate assessment.
What this interaction means in plain words
Cyproheptadine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects from H1 antagonism and dopamine D2 blockade.
What to do
Monitor for oversedation and anticholinergic effects, and keep the usual ECG and electrolyte monitoring for pimozide. Avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Cyproheptadine with Pimozide?
MediHelp rates the interaction as moderate. Cyproheptadine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation and have anticholinergic activity, so combined use can increase drowsiness and cognitive slowing. Pimozide also carries QT-prolongation risk, so any additional adverse effects such as sedation or confusion complicate assessment.
How serious is the interaction between Cyproheptadine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic effects, and keep the usual ECG and electrolyte monitoring for pimozide. Avoid alcohol and other sedatives.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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