Drug interactions
Cyproheptadine + Scullcap
Severity: Moderate
Cyproheptadine and Scullcap: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Skullcap is used as a mild sedative herb and may add to the drowsiness caused by cyproheptadine. Evidence is limited and the effect is probably modest.
What this interaction means in plain words
Cyproheptadine and Scullcap can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, probably through GABAergic activity of the herb.
What to do
Advise patients to monitor for excess drowsiness and avoid driving if affected. Consider stopping the herbal product if sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyproheptadine and Scullcap, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Frequently asked questions
Can I take Cyproheptadine with Scullcap?
MediHelp rates the interaction as moderate. Cyproheptadine and Scullcap can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Skullcap is used as a mild sedative herb and may add to the drowsiness caused by cyproheptadine. Evidence is limited and the effect is probably modest.
How serious is the interaction between Cyproheptadine and Scullcap?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to monitor for excess drowsiness and avoid driving if affected. Consider stopping the herbal product if sedation occurs.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
