Drug interactions
Cyproheptadine + Sumatriptan intranasal
Severity: Moderate
Cyproheptadine and Sumatriptan intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyproheptadine blocks serotonin receptors and may reduce the effectiveness of triptans, so migraine relief could be diminished. The effect is based on mechanism and limited reports.
What this interaction means in plain words
Cyproheptadine and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at serotonin receptors by cyproheptadine.
What to do
Monitor for reduced migraine response and consider whether cyproheptadine is needed. Use an alternative if the triptan appears ineffective.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Frequently asked questions
Can I take Cyproheptadine with Sumatriptan intranasal?
MediHelp rates the interaction as moderate. Cyproheptadine and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyproheptadine blocks serotonin receptors and may reduce the effectiveness of triptans, so migraine relief could be diminished. The effect is based on mechanism and limited reports.
How serious is the interaction between Cyproheptadine and Sumatriptan intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced migraine response and consider whether cyproheptadine is needed. Use an alternative if the triptan appears ineffective.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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