Drug interactions
Cyproheptadine + Triazolam
Severity: Moderate
Cyproheptadine and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triazolam is a potent short-acting benzodiazepine, and with cyproheptadine it can cause greater drowsiness, impaired cognition and coordination.
What this interaction means in plain words
Cyproheptadine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and H1 blockade.
What to do
Use the lowest effective triazolam dose and monitor for oversedation and impaired psychomotor function. Advise against alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Frequently asked questions
Can I take Cyproheptadine with Triazolam?
MediHelp rates the interaction as moderate. Cyproheptadine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triazolam is a potent short-acting benzodiazepine, and with cyproheptadine it can cause greater drowsiness, impaired cognition and coordination.
How serious is the interaction between Cyproheptadine and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective triazolam dose and monitor for oversedation and impaired psychomotor function. Advise against alcohol and driving.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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