Drug interactions
Cytarabine + Etrasimod
Severity: Major
Cytarabine and Etrasimod: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod lowers circulating lymphocytes, and cytarabine is myelosuppressive and immunosuppressive. Together they may increase the risk of serious infection, and this combination has not been studied.
What this interaction means in plain words
Cytarabine and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cytarabine belongs to Oncology; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression from S1P receptor modulation (lymphocyte sequestration) and cytotoxic marrow suppression.
What to do
Avoid starting etrasimod during cytarabine therapy and for the recovery period afterward. If combined, monitor lymphocyte and neutrophil counts and watch for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cytarabine
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Cytarabine with Etrasimod?
MediHelp rates the interaction as major. Cytarabine and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod lowers circulating lymphocytes, and cytarabine is myelosuppressive and immunosuppressive. Together they may increase the risk of serious infection, and this combination has not been studied.
How serious is the interaction between Cytarabine and Etrasimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting etrasimod during cytarabine therapy and for the recovery period afterward. If combined, monitor lymphocyte and neutrophil counts and watch for infection.
What other medicines interact with Cytarabine?
MediHelp also lists interactions of Cytarabine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Cytarabine page.
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