Drug interactions
Cytomegalovirus immune globulin + Measles mumps and rubella vaccine
Severity: Moderate
Cytomegalovirus immune globulin and Measles mumps and rubella vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibodies in cytomegalovirus immune globulin can neutralize the live attenuated vaccine viruses before they replicate adequately. This may result in a weaker or absent immune response and leave the patient unprotected despite vaccination.
What this interaction means in plain words
Cytomegalovirus immune globulin and Measles mumps and rubella vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Passively transferred antibodies neutralize live vaccine virus and blunt vaccine virus replication and immunogenicity.
What to do
Defer MMR vaccination for an interval of several months after the immune globulin, following the product-specific interval in current immunization guidance (often 3 months or longer for IV products). Consider checking serology or revaccinating if the vaccine was given too soon.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Frequently asked questions
Can I take Cytomegalovirus immune globulin with Measles mumps and rubella vaccine?
MediHelp rates the interaction as moderate. Cytomegalovirus immune globulin and Measles mumps and rubella vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antibodies in cytomegalovirus immune globulin can neutralize the live attenuated vaccine viruses before they replicate adequately. This may result in a weaker or absent immune response and leave the patient unprotected despite vaccination.
How serious is the interaction between Cytomegalovirus immune globulin and Measles mumps and rubella vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Defer MMR vaccination for an interval of several months after the immune globulin, following the product-specific interval in current immunization guidance (often 3 months or longer for IV products). Consider checking serology or revaccinating if the vaccine was given too soon.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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