Drug interactions
Dabigatran + Nifedipine
Severity: Minor
Dabigatran and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine is a weak P-glycoprotein inhibitor and may slightly raise dabigatran exposure, with theoretical increase in bleeding risk, particularly in renal impairment.
What this interaction means in plain words
Dabigatran and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak inhibition of intestinal P-glycoprotein efflux of dabigatran etexilate.
What to do
Assess renal function before and during therapy and monitor for bleeding, especially if creatinine clearance is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Frequently asked questions
Can I take Dabigatran with Nifedipine?
MediHelp rates the interaction as minor. Dabigatran and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine is a weak P-glycoprotein inhibitor and may slightly raise dabigatran exposure, with theoretical increase in bleeding risk, particularly in renal impairment.
How serious is the interaction between Dabigatran and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess renal function before and during therapy and monitor for bleeding, especially if creatinine clearance is reduced.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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