Drug interactions
Dabigatran + Tamoxifen
Severity: Moderate
Dabigatran and Tamoxifen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tamoxifen and its metabolites inhibit P-glycoprotein, which may raise dabigatran exposure. Higher dabigatran levels increase bleeding risk, particularly in patients with renal impairment.
What this interaction means in plain words
Dabigatran and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
P-glycoprotein inhibition reduces intestinal efflux and renal clearance of dabigatran etexilate and dabigatran.
What to do
Monitor for bleeding and check renal function, and follow labeled dabigatran restrictions with P-gp inhibitors in renal impairment. Consider an alternative anticoagulant if bleeding risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Frequently asked questions
Can I take Dabigatran with Tamoxifen?
MediHelp rates the interaction as moderate. Dabigatran and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tamoxifen and its metabolites inhibit P-glycoprotein, which may raise dabigatran exposure. Higher dabigatran levels increase bleeding risk, particularly in patients with renal impairment.
How serious is the interaction between Dabigatran and Tamoxifen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and check renal function, and follow labeled dabigatran restrictions with P-gp inhibitors in renal impairment. Consider an alternative anticoagulant if bleeding risk is high.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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