Drug interactions
Dabigatran + Tirofiban
Severity: Major
Dabigatran and Tirofiban: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabigatran, a direct thrombin inhibitor, and tirofiban, a platelet inhibitor, both impair hemostasis. Giving them together increases the risk of major bleeding.
What this interaction means in plain words
Dabigatran and Tirofiban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic effects of thrombin inhibition and glycoprotein IIb/IIIa receptor blockade.
What to do
Avoid the combination where possible, or monitor closely for bleeding, renal function and hemoglobin. Use the shortest duration of concurrent therapy needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tirofiban
Frequently asked questions
Can I take Dabigatran with Tirofiban?
MediHelp rates the interaction as major. Dabigatran and Tirofiban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dabigatran, a direct thrombin inhibitor, and tirofiban, a platelet inhibitor, both impair hemostasis. Giving them together increases the risk of major bleeding.
How serious is the interaction between Dabigatran and Tirofiban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor closely for bleeding, renal function and hemoglobin. Use the shortest duration of concurrent therapy needed.
What other medicines interact with Tirofiban?
MediHelp also lists interactions of Tirofiban with, for example, Abrocitinib, Acalabrutinib, Acetylsalicylic acid. The full list is on the Tirofiban page.
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