Drug interactions
Dabigatran + Tolmetin
Severity: Major
Dabigatran and Tolmetin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolmetin is an NSAID that inhibits platelet function and can injure the gastric mucosa, while dabigatran is an oral direct thrombin inhibitor. Taken together they raise the risk of clinically significant bleeding, especially from the gastrointestinal tract.
What this interaction means in plain words
Dabigatran and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic effects: NSAID-induced platelet inhibition and mucosal injury plus thrombin inhibition by dabigatran.
What to do
Avoid the combination where possible and use a non-NSAID analgesic such as paracetamol. If it cannot be avoided, use the shortest NSAID course, consider gastroprotection, and monitor for bleeding and falling hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Dabigatran with Tolmetin?
MediHelp rates the interaction as major. Dabigatran and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tolmetin is an NSAID that inhibits platelet function and can injure the gastric mucosa, while dabigatran is an oral direct thrombin inhibitor. Taken together they raise the risk of clinically significant bleeding, especially from the gastrointestinal tract.
How serious is the interaction between Dabigatran and Tolmetin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use a non-NSAID analgesic such as paracetamol. If it cannot be avoided, use the shortest NSAID course, consider gastroprotection, and monitor for bleeding and falling hemoglobin.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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