Drug interactions
Dabigatran etexilate + Danshen
Severity: Moderate
Dabigatran etexilate and Danshen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danshen (Salvia miltiorrhiza) has antiplatelet and anticoagulant activity and has been associated with bleeding and increased INR with warfarin. It may add to dabigatran bleeding risk.
What this interaction means in plain words
Dabigatran etexilate and Danshen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet and anticoagulant activity from herbal constituents.
What to do
Advise patients to avoid danshen while on dabigatran. Monitor for bleeding if use cannot be avoided.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Frequently asked questions
Can I take Dabigatran etexilate with Danshen?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Danshen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danshen (Salvia miltiorrhiza) has antiplatelet and anticoagulant activity and has been associated with bleeding and increased INR with warfarin. It may add to dabigatran bleeding risk.
How serious is the interaction between Dabigatran etexilate and Danshen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid danshen while on dabigatran. Monitor for bleeding if use cannot be avoided.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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