Drug interactions
Dabigatran etexilate + Deferasirox
Severity: Moderate
Dabigatran etexilate and Deferasirox: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can cause gastrointestinal ulceration and hemorrhage, and may also reduce renal function. Combined with dabigatran, the chance of serious gastrointestinal bleeding is increased, and renal impairment can further increase dabigatran exposure.
What this interaction means in plain words
Dabigatran etexilate and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Deferasirox belongs to Miscellaneous.
Why it happens
Additive bleeding risk from deferasirox-related mucosal injury and dabigatran anticoagulation, with possible reduced dabigatran renal clearance.
What to do
Monitor for gastrointestinal bleeding, hemoglobin and renal function. Consider gastroprotection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dabigatran etexilate and Deferasirox, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Dabigatran etexilate with Deferasirox?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can cause gastrointestinal ulceration and hemorrhage, and may also reduce renal function. Combined with dabigatran, the chance of serious gastrointestinal bleeding is increased, and renal impairment can further increase dabigatran exposure.
How serious is the interaction between Dabigatran etexilate and Deferasirox?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal bleeding, hemoglobin and renal function. Consider gastroprotection.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
