Drug interactions
Dabigatran etexilate + Erythromycin base
Severity: Moderate
Dabigatran etexilate and Erythromycin base: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits P-glycoprotein and may modestly increase dabigatran exposure. This raises the chance of bleeding, especially when kidney function is impaired.
What this interaction means in plain words
Dabigatran etexilate and Erythromycin base can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Erythromycin inhibits P-glycoprotein-mediated efflux of dabigatran etexilate, increasing absorption.
What to do
Monitor for bleeding and renal function during the antibiotic course. Avoid the combination in patients with significant renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Frequently asked questions
Can I take Dabigatran etexilate with Erythromycin base?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Erythromycin base can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits P-glycoprotein and may modestly increase dabigatran exposure. This raises the chance of bleeding, especially when kidney function is impaired.
How serious is the interaction between Dabigatran etexilate and Erythromycin base?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function during the antibiotic course. Avoid the combination in patients with significant renal impairment.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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