Drug interactions
Dabigatran etexilate + Fenoprofen
Severity: Major
Dabigatran etexilate and Fenoprofen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoprofen is an NSAID that raises bleeding risk with dabigatran through gastrointestinal injury and platelet inhibition. NSAID-related renal impairment may further raise dabigatran levels.
What this interaction means in plain words
Dabigatran etexilate and Fenoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabigatran etexilate belongs to Cardiovascular; Fenoprofen belongs to Musculoskeletal.
Why it happens
Additive hemostatic impairment from NSAID effects with direct thrombin inhibition, plus possible reduced dabigatran renal clearance.
What to do
Avoid regular use and choose a non-NSAID analgesic. If unavoidable, use briefly with gastroprotection and monitor for bleeding and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Dabigatran etexilate with Fenoprofen?
MediHelp rates the interaction as major. Dabigatran etexilate and Fenoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fenoprofen is an NSAID that raises bleeding risk with dabigatran through gastrointestinal injury and platelet inhibition. NSAID-related renal impairment may further raise dabigatran levels.
How serious is the interaction between Dabigatran etexilate and Fenoprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use and choose a non-NSAID analgesic. If unavoidable, use briefly with gastroprotection and monitor for bleeding and renal function.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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