Drug interactions
Dabigatran etexilate + Glecaprevir / pibrentasvir
Severity: Major
Dabigatran etexilate and Glecaprevir / pibrentasvir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein and can increase dabigatran exposure, raising bleeding risk. Labeling advises caution with this combination.
What this interaction means in plain words
Dabigatran etexilate and Glecaprevir / pibrentasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of intestinal P-glycoprotein increases dabigatran etexilate absorption.
What to do
Monitor closely for bleeding and renal function, and consider reducing or avoiding dabigatran in renal impairment. Consider an alternative anticoagulant during HCV therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Frequently asked questions
Can I take Dabigatran etexilate with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as major. Dabigatran etexilate and Glecaprevir / pibrentasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glecaprevir and pibrentasvir inhibit P-glycoprotein and can increase dabigatran exposure, raising bleeding risk. Labeling advises caution with this combination.
How serious is the interaction between Dabigatran etexilate and Glecaprevir / pibrentasvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for bleeding and renal function, and consider reducing or avoiding dabigatran in renal impairment. Consider an alternative anticoagulant during HCV therapy.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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