Drug interactions
Dabigatran etexilate + Grapefruit
Severity: Minor
Dabigatran etexilate and Grapefruit: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit has weak P-glycoprotein effects, and no clinically meaningful change in dabigatran exposure is well established. Any effect is likely small.
What this interaction means in plain words
Dabigatran etexilate and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak intestinal P-glycoprotein inhibition by grapefruit components; not well established.
What to do
No routine action is needed; avoid very large grapefruit intake in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Frequently asked questions
Can I take Dabigatran etexilate with Grapefruit?
MediHelp rates the interaction as minor. Dabigatran etexilate and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit has weak P-glycoprotein effects, and no clinically meaningful change in dabigatran exposure is well established. Any effect is likely small.
How serious is the interaction between Dabigatran etexilate and Grapefruit?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; avoid very large grapefruit intake in patients with renal impairment.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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