Drug interactions
Dabigatran etexilate + Icosapent
Severity: Moderate
Dabigatran etexilate and Icosapent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icosapent ethyl may prolong bleeding time slightly and has been associated with more bleeding when used with anticoagulants. The combined effect can increase bleeding risk.
What this interaction means in plain words
Dabigatran etexilate and Icosapent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect through mild platelet inhibition on top of thrombin inhibition.
What to do
Monitor for bleeding signs periodically; no dose change is routinely required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Frequently asked questions
Can I take Dabigatran etexilate with Icosapent?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Icosapent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Icosapent ethyl may prolong bleeding time slightly and has been associated with more bleeding when used with anticoagulants. The combined effect can increase bleeding risk.
How serious is the interaction between Dabigatran etexilate and Icosapent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs periodically; no dose change is routinely required.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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