Drug interactions
Dabigatran etexilate + Nefazodone
Severity: Moderate
Dabigatran etexilate and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone may inhibit intestinal P-gp, which could increase dabigatran exposure and bleeding risk. Data on the size of this effect are limited, but it is plausible in patients with reduced renal function.
What this interaction means in plain words
Dabigatran etexilate and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible inhibition of P-glycoprotein efflux of dabigatran by nefazodone.
What to do
Monitor for bleeding and renal function; prefer an alternative antidepressant such as an SSRI with lower interaction potential where feasible. Avoid in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Frequently asked questions
Can I take Dabigatran etexilate with Nefazodone?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone may inhibit intestinal P-gp, which could increase dabigatran exposure and bleeding risk. Data on the size of this effect are limited, but it is plausible in patients with reduced renal function.
How serious is the interaction between Dabigatran etexilate and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function; prefer an alternative antidepressant such as an SSRI with lower interaction potential where feasible. Avoid in patients with renal impairment.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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