Drug interactions
Dabigatran etexilate + Ponatinib
Severity: Moderate
Dabigatran etexilate and Ponatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib inhibits P-glycoprotein and may raise dabigatran exposure. Ponatinib itself is associated with bleeding and thrombotic events, so the combination increases bleeding concern.
What this interaction means in plain words
Dabigatran etexilate and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Ponatinib belongs to Oncology.
Why it happens
Ponatinib inhibits P-glycoprotein efflux of dabigatran etexilate, increasing absorption, plus additive bleeding tendency.
What to do
Monitor for bleeding and renal function. Avoid the combination or reduce dabigatran dose per labeling when creatinine clearance is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Ponatinib
Frequently asked questions
Can I take Dabigatran etexilate with Ponatinib?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponatinib inhibits P-glycoprotein and may raise dabigatran exposure. Ponatinib itself is associated with bleeding and thrombotic events, so the combination increases bleeding concern.
How serious is the interaction between Dabigatran etexilate and Ponatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function. Avoid the combination or reduce dabigatran dose per labeling when creatinine clearance is reduced.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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