Drug interactions
Dabigatran etexilate + Progesterone micronized
Severity: Minor
Dabigatran etexilate and Progesterone micronized: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progesterone has weak P-glycoprotein inhibitory activity in vitro, so any increase in dabigatran exposure is likely small and of uncertain clinical significance.
What this interaction means in plain words
Dabigatran etexilate and Progesterone micronized have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Progesterone may weakly inhibit P-glycoprotein efflux of dabigatran etexilate.
What to do
No dose change is generally required; be alert for bleeding, particularly in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Frequently asked questions
Can I take Dabigatran etexilate with Progesterone micronized?
MediHelp rates the interaction as minor. Dabigatran etexilate and Progesterone micronized have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progesterone has weak P-glycoprotein inhibitory activity in vitro, so any increase in dabigatran exposure is likely small and of uncertain clinical significance.
How serious is the interaction between Dabigatran etexilate and Progesterone micronized?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required; be alert for bleeding, particularly in patients with renal impairment.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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