Drug interactions
Dabigatran etexilate + Prothrombin complex concentrate human
Severity: Moderate
Dabigatran etexilate and Prothrombin complex concentrate human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prothrombin complex concentrate is used to reverse dabigatran in life-threatening bleeding, so the pair is a therapeutic opposition rather than a true contraindication. Giving it to patients on dabigatran carries a thrombotic risk, and idarucizumab is the preferred specific reversal agent.
What this interaction means in plain words
Dabigatran etexilate and Prothrombin complex concentrate human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: concentrated clotting factors counteract direct thrombin inhibition, with potential prothrombotic effect.
What to do
Use only for serious bleeding when idarucizumab is unavailable, and monitor for thromboembolism. Restart anticoagulation when bleeding is controlled.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Frequently asked questions
Can I take Dabigatran etexilate with Prothrombin complex concentrate human?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Prothrombin complex concentrate human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prothrombin complex concentrate is used to reverse dabigatran in life-threatening bleeding, so the pair is a therapeutic opposition rather than a true contraindication. Giving it to patients on dabigatran carries a thrombotic risk, and idarucizumab is the preferred specific reversal agent.
How serious is the interaction between Dabigatran etexilate and Prothrombin complex concentrate human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only for serious bleeding when idarucizumab is unavailable, and monitor for thromboembolism. Restart anticoagulation when bleeding is controlled.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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