Drug interactions
Dabigatran etexilate + Salsalate
Severity: Moderate
Dabigatran etexilate and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a nonacetylated salicylate that inhibits platelet function less than aspirin, but NSAID-type effects and gastric irritation can still raise bleeding risk with dabigatran. Risk is mainly gastrointestinal.
What this interaction means in plain words
Dabigatran etexilate and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive bleeding risk from salicylate effects on platelets and gastric mucosa combined with anticoagulation.
What to do
Prefer paracetamol where analgesia is needed; if salsalate is used, monitor for bleeding and consider gastroprotection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Frequently asked questions
Can I take Dabigatran etexilate with Salsalate?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a nonacetylated salicylate that inhibits platelet function less than aspirin, but NSAID-type effects and gastric irritation can still raise bleeding risk with dabigatran. Risk is mainly gastrointestinal.
How serious is the interaction between Dabigatran etexilate and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer paracetamol where analgesia is needed; if salsalate is used, monitor for bleeding and consider gastroprotection.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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