Drug interactions
Dabigatran etexilate + Tenofovir df
Severity: Minor
Dabigatran etexilate and Tenofovir df: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is not a P-gp inducer and no clinically meaningful reduction in dabigatran exposure is expected. No established interaction supports the legacy claim.
What this interaction means in plain words
Dabigatran etexilate and Tenofovir df have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established pharmacokinetic or pharmacodynamic mechanism; both drugs are renally eliminated, so renal function matters for each.
What to do
No dose adjustment is needed for this pair. Monitor renal function, since tenofovir nephrotoxicity could increase dabigatran exposure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Frequently asked questions
Can I take Dabigatran etexilate with Tenofovir df?
MediHelp rates the interaction as minor. Dabigatran etexilate and Tenofovir df have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tenofovir is not a P-gp inducer and no clinically meaningful reduction in dabigatran exposure is expected. No established interaction supports the legacy claim.
How serious is the interaction between Dabigatran etexilate and Tenofovir df?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed for this pair. Monitor renal function, since tenofovir nephrotoxicity could increase dabigatran exposure.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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