Drug interactions
Dabigatran etexilate + Vorapaxar
Severity: Major
Dabigatran etexilate and Vorapaxar: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorapaxar is a PAR-1 antiplatelet with a long half-life and combining it with an anticoagulant raises the risk of major bleeding, including intracranial hemorrhage.
What this interaction means in plain words
Dabigatran etexilate and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive effects on hemostasis: PAR-1 platelet inhibition combined with thrombin inhibition.
What to do
Avoid unless clearly indicated; vorapaxar is contraindicated with prior stroke or intracranial hemorrhage. Monitor for bleeding and hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Frequently asked questions
Can I take Dabigatran etexilate with Vorapaxar?
MediHelp rates the interaction as major. Dabigatran etexilate and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vorapaxar is a PAR-1 antiplatelet with a long half-life and combining it with an anticoagulant raises the risk of major bleeding, including intracranial hemorrhage.
How serious is the interaction between Dabigatran etexilate and Vorapaxar?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless clearly indicated; vorapaxar is contraindicated with prior stroke or intracranial hemorrhage. Monitor for bleeding and hemoglobin.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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