Drug interactions
Dabrafenib + Diazepam
Severity: Moderate
Dabrafenib and Diazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and CYP2C enzymes and may lower diazepam concentrations, potentially reducing its effect. The change may be gradual as induction develops over days to weeks.
What this interaction means in plain words
Dabrafenib and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Diazepam belongs to Musculoskeletal.
Why it happens
Enzyme induction by dabrafenib accelerates diazepam metabolism.
What to do
Monitor for reduced diazepam effect and raise the dose if needed. Watch for increased sedation if dabrafenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Diazepam?
MediHelp rates the interaction as moderate. Dabrafenib and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and CYP2C enzymes and may lower diazepam concentrations, potentially reducing its effect. The change may be gradual as induction develops over days to weeks.
How serious is the interaction between Dabrafenib and Diazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced diazepam effect and raise the dose if needed. Watch for increased sedation if dabrafenib is stopped.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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