Drug interactions
Dabrafenib + Docetaxel
Severity: Moderate
Dabrafenib and Docetaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower docetaxel exposure, potentially reducing efficacy.
What this interaction means in plain words
Dabrafenib and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Docetaxel belongs to Oncology.
Why it happens
Dabrafenib induces CYP3A4, increasing docetaxel metabolism.
What to do
Monitor tumor response and for reduced docetaxel effect; consider alternatives if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Docetaxel?
MediHelp rates the interaction as moderate. Dabrafenib and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may lower docetaxel exposure, potentially reducing efficacy.
How serious is the interaction between Dabrafenib and Docetaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and for reduced docetaxel effect; consider alternatives if feasible.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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