Drug interactions
Dabrafenib + Efavirenz
Severity: Major
Dabrafenib and Efavirenz: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib is metabolized by CYP3A4 and CYP2C8, and efavirenz may reduce its concentrations through enzyme induction, potentially diminishing efficacy. Dabrafenib is itself an inducer, so efavirenz exposure may also fall.
What this interaction means in plain words
Dabrafenib and Efavirenz can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabrafenib belongs to Oncology; Efavirenz belongs to Anti Virals.
Why it happens
Efavirenz induces CYP3A4/CYP2C8 metabolism of dabrafenib, and dabrafenib induces CYP3A4 in turn.
What to do
Substitute a non-inducing antiretroviral where possible. If coadministered, monitor tumor response and HIV viral load.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Efavirenz?
MediHelp rates the interaction as major. Dabrafenib and Efavirenz can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dabrafenib is metabolized by CYP3A4 and CYP2C8, and efavirenz may reduce its concentrations through enzyme induction, potentially diminishing efficacy. Dabrafenib is itself an inducer, so efavirenz exposure may also fall.
How serious is the interaction between Dabrafenib and Efavirenz?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Substitute a non-inducing antiretroviral where possible. If coadministered, monitor tumor response and HIV viral load.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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