Drug interactions
Dabrafenib + Erythromycin
Severity: Moderate
Dabrafenib and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower erythromycin exposure, reducing efficacy. Erythromycin may also modestly raise dabrafenib concentrations.
What this interaction means in plain words
Dabrafenib and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Erythromycin belongs to Anti Bacterial.
Why it happens
Induction of CYP3A4 by dabrafenib accelerates erythromycin metabolism.
What to do
Monitor for reduced antibiotic efficacy, or use an alternative such as azithromycin. Monitor dabrafenib adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Erythromycin?
MediHelp rates the interaction as moderate. Dabrafenib and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may lower erythromycin exposure, reducing efficacy. Erythromycin may also modestly raise dabrafenib concentrations.
How serious is the interaction between Dabrafenib and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antibiotic efficacy, or use an alternative such as azithromycin. Monitor dabrafenib adverse effects.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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