Drug interactions
Dabrafenib + Fluticasone-salmeterol
Severity: Minor
Dabrafenib and Fluticasone-salmeterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib is a CYP3A4 inducer and may lower salmeterol and fluticasone exposure. With inhaled doses the effect is probably small, though reduced control of airway disease could occur.
What this interaction means in plain words
Dabrafenib and Fluticasone-salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabrafenib belongs to Oncology; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Induction of CYP3A4 by dabrafenib increases the clearance of salmeterol and fluticasone.
What to do
Monitor asthma or COPD control when dabrafenib is started or stopped. Step up inhaled therapy only if symptoms worsen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Fluticasone-salmeterol?
MediHelp rates the interaction as minor. Dabrafenib and Fluticasone-salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib is a CYP3A4 inducer and may lower salmeterol and fluticasone exposure. With inhaled doses the effect is probably small, though reduced control of airway disease could occur.
How serious is the interaction between Dabrafenib and Fluticasone-salmeterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma or COPD control when dabrafenib is started or stopped. Step up inhaled therapy only if symptoms worsen.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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