Drug interactions
Dabrafenib + Glipizide-metformin
Severity: Moderate
Dabrafenib and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib can cause hyperglycemia, which may worsen control in patients with diabetes. Dabrafenib is also a CYP3A4 and CYP2C9 inducer, so it may lower glipizide exposure.
What this interaction means in plain words
Dabrafenib and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Glipizide-metformin belongs to Endocrine.
Why it happens
Dabrafenib-associated hyperglycemia opposes antidiabetic therapy, and enzyme induction may increase glipizide metabolism.
What to do
Check glucose at baseline and regularly during dabrafenib therapy and adjust antidiabetic treatment accordingly. Reassess doses when dabrafenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Glipizide-metformin?
MediHelp rates the interaction as moderate. Dabrafenib and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib can cause hyperglycemia, which may worsen control in patients with diabetes. Dabrafenib is also a CYP3A4 and CYP2C9 inducer, so it may lower glipizide exposure.
How serious is the interaction between Dabrafenib and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check glucose at baseline and regularly during dabrafenib therapy and adjust antidiabetic treatment accordingly. Reassess doses when dabrafenib is stopped.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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