Drug interactions
Dabrafenib + Ifosfamide
Severity: Moderate
Dabrafenib and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and CYP2B6, which can speed ifosfamide activation and increase formation of chloroacetaldehyde, a neurotoxic and nephrotoxic metabolite. This may raise the risk of encephalopathy and renal tubular injury.
What this interaction means in plain words
Dabrafenib and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Ifosfamide belongs to Oncology.
Why it happens
Dabrafenib induces CYP3A4 and CYP2B6, increasing ifosfamide metabolism including toxic metabolite formation.
What to do
Monitor closely for CNS toxicity, renal function and myelosuppression, and consider ifosfamide dose adjustment. Ensure standard mesna and hydration prophylaxis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Ifosfamide?
MediHelp rates the interaction as moderate. Dabrafenib and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and CYP2B6, which can speed ifosfamide activation and increase formation of chloroacetaldehyde, a neurotoxic and nephrotoxic metabolite. This may raise the risk of encephalopathy and renal tubular injury.
How serious is the interaction between Dabrafenib and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for CNS toxicity, renal function and myelosuppression, and consider ifosfamide dose adjustment. Ensure standard mesna and hydration prophylaxis.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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