Drug interactions
Dabrafenib + Isosorbide dinitrate
Severity: Minor
Dabrafenib and Isosorbide dinitrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may modestly lower exposure to some co-administered drugs. Isosorbide dinitrate is cleared mainly by denitration in the liver rather than by CYP3A4, so a meaningful loss of antianginal effect is unlikely.
What this interaction means in plain words
Dabrafenib and Isosorbide dinitrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabrafenib belongs to Oncology; Isosorbide dinitrate belongs to Cardiovascular.
Why it happens
Dabrafenib induces CYP3A4, which plays only a minor role in isosorbide dinitrate clearance.
What to do
No dose change is normally needed. Reassess angina control if symptoms worsen after dabrafenib is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide dinitrate Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Isosorbide dinitrate?
MediHelp rates the interaction as minor. Dabrafenib and Isosorbide dinitrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib induces CYP3A4 and may modestly lower exposure to some co-administered drugs. Isosorbide dinitrate is cleared mainly by denitration in the liver rather than by CYP3A4, so a meaningful loss of antianginal effect is unlikely.
How serious is the interaction between Dabrafenib and Isosorbide dinitrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed. Reassess angina control if symptoms worsen after dabrafenib is started.
What other medicines interact with Isosorbide dinitrate?
MediHelp also lists interactions of Isosorbide dinitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide dinitrate page.
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