Drug interactions
Dabrafenib + Ketoconazole
Severity: Moderate
Dabrafenib and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole increases dabrafenib exposure, which may worsen its adverse effects such as pyrexia, rash and hyperglycemia. Dabrafenib is also a CYP3A4 inducer, which may lower ketoconazole levels in turn.
What this interaction means in plain words
Dabrafenib and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Ketoconazole belongs to Anti Fungals.
Why it happens
Ketoconazole inhibits CYP3A4 (and CYP2C8) metabolism of dabrafenib.
What to do
Prefer an alternative antifungal that is not a strong CYP3A4 inhibitor. If combined, monitor closely for dabrafenib toxicity and consider dose reduction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Ketoconazole?
MediHelp rates the interaction as moderate. Dabrafenib and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole increases dabrafenib exposure, which may worsen its adverse effects such as pyrexia, rash and hyperglycemia. Dabrafenib is also a CYP3A4 inducer, which may lower ketoconazole levels in turn.
How serious is the interaction between Dabrafenib and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antifungal that is not a strong CYP3A4 inhibitor. If combined, monitor closely for dabrafenib toxicity and consider dose reduction.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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