Drug interactions
Dabrafenib + Levonorgestrel
Severity: Moderate
Dabrafenib and Levonorgestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower systemic levonorgestrel levels. This could reduce the efficacy of oral or emergency levonorgestrel, whereas the intrauterine system acts mainly locally and is much less affected.
What this interaction means in plain words
Dabrafenib and Levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Levonorgestrel belongs to Endocrine.
Why it happens
Dabrafenib induces CYP3A4, increasing levonorgestrel metabolism.
What to do
Use an intrauterine system or add a nonhormonal method; avoid relying on oral levonorgestrel. Continue the extra protection for 2 weeks after the last dabrafenib dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levonorgestrel
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Levonorgestrel?
MediHelp rates the interaction as moderate. Dabrafenib and Levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may lower systemic levonorgestrel levels. This could reduce the efficacy of oral or emergency levonorgestrel, whereas the intrauterine system acts mainly locally and is much less affected.
How serious is the interaction between Dabrafenib and Levonorgestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an intrauterine system or add a nonhormonal method; avoid relying on oral levonorgestrel. Continue the extra protection for 2 weeks after the last dabrafenib dose.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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