Drug interactions
Dabrafenib + Lorlatinib
Severity: Major
Dabrafenib and Lorlatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4, and strong or moderate CYP3A induction lowers lorlatinib exposure. This may reduce antitumour efficacy and has been linked with liver enzyme elevations.
What this interaction means in plain words
Dabrafenib and Lorlatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabrafenib belongs to Oncology; Lorlatinib belongs to Oncology.
Why it happens
CYP3A4 induction by dabrafenib increases lorlatinib metabolism.
What to do
Avoid the combination where possible. If unavoidable, monitor liver enzymes and disease response closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Lorlatinib?
MediHelp rates the interaction as major. Dabrafenib and Lorlatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dabrafenib induces CYP3A4, and strong or moderate CYP3A induction lowers lorlatinib exposure. This may reduce antitumour efficacy and has been linked with liver enzyme elevations.
How serious is the interaction between Dabrafenib and Lorlatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If unavoidable, monitor liver enzymes and disease response closely.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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