Drug interactions
Dabrafenib + Methadone
Severity: Moderate
Dabrafenib and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib may reduce methadone concentrations, potentially causing withdrawal symptoms or reduced pain control. Stopping dabrafenib may lead to a rebound rise in methadone levels and toxicity.
What this interaction means in plain words
Dabrafenib and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Methadone belongs to Musculoskeletal.
Why it happens
Dabrafenib induces CYP3A4 and CYP2B6, increasing the metabolism of methadone.
What to do
Monitor for withdrawal and inadequate analgesia, and increase the methadone dose if needed. Reduce the dose again and watch for sedation if dabrafenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Methadone?
MediHelp rates the interaction as moderate. Dabrafenib and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib may reduce methadone concentrations, potentially causing withdrawal symptoms or reduced pain control. Stopping dabrafenib may lead to a rebound rise in methadone levels and toxicity.
How serious is the interaction between Dabrafenib and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for withdrawal and inadequate analgesia, and increase the methadone dose if needed. Reduce the dose again and watch for sedation if dabrafenib is stopped.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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