Drug interactions
Dabrafenib + Netupitant-palonosetron
Severity: Moderate
Dabrafenib and Netupitant-palonosetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may reduce netupitant concentrations. This could lessen protection against chemotherapy-induced nausea and vomiting.
What this interaction means in plain words
Dabrafenib and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Netupitant-palonosetron belongs to Gastrointestinal Tract.
Why it happens
CYP3A4 induction by dabrafenib increases netupitant clearance.
What to do
Monitor antiemetic efficacy and add or substitute other antiemetic agents if breakthrough nausea occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Netupitant-palonosetron?
MediHelp rates the interaction as moderate. Dabrafenib and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may reduce netupitant concentrations. This could lessen protection against chemotherapy-induced nausea and vomiting.
How serious is the interaction between Dabrafenib and Netupitant-palonosetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antiemetic efficacy and add or substitute other antiemetic agents if breakthrough nausea occurs.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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