Drug interactions
Dabrafenib + Nifedipine
Severity: Moderate
Dabrafenib and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower nifedipine exposure. This can lead to loss of blood pressure or angina control.
What this interaction means in plain words
Dabrafenib and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Nifedipine belongs to Cardiovascular.
Why it happens
Dabrafenib induces CYP3A4, increasing nifedipine metabolism.
What to do
Monitor blood pressure and symptoms after starting dabrafenib. Increase the nifedipine dose as needed, or choose an alternative antihypertensive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Nifedipine?
MediHelp rates the interaction as moderate. Dabrafenib and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may lower nifedipine exposure. This can lead to loss of blood pressure or angina control.
How serious is the interaction between Dabrafenib and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms after starting dabrafenib. Increase the nifedipine dose as needed, or choose an alternative antihypertensive.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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