Drug interactions
Dabrafenib + Pantoprazole
Severity: Moderate
Dabrafenib and Pantoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib solubility falls as gastric pH rises, so acid suppression may reduce its absorption. Dabrafenib also induces CYP enzymes and may lower pantoprazole exposure. Either effect may reduce efficacy of the respective drug.
What this interaction means in plain words
Dabrafenib and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH decreases dabrafenib dissolution, and dabrafenib induction of CYP2C19 and CYP3A4 increases pantoprazole metabolism.
What to do
Monitor tumor response and control of acid-related symptoms. Increase the pantoprazole dose if symptoms are not controlled.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Pantoprazole?
MediHelp rates the interaction as moderate. Dabrafenib and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib solubility falls as gastric pH rises, so acid suppression may reduce its absorption. Dabrafenib also induces CYP enzymes and may lower pantoprazole exposure. Either effect may reduce efficacy of the respective drug.
How serious is the interaction between Dabrafenib and Pantoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and control of acid-related symptoms. Increase the pantoprazole dose if symptoms are not controlled.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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