Drug interactions
Pantoprazole + Rilpivirine
Severity: Contraindicated
Pantoprazole and Rilpivirine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral rilpivirine requires acidic gastric conditions for absorption, and pantoprazole markedly reduces its exposure. This can cause virologic failure and NNRTI resistance, and labeling contraindicates PPIs with oral rilpivirine.
What this interaction means in plain words
Pantoprazole and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pantoprazole belongs to Gastrointestinal Tract; Rilpivirine belongs to Anti Virals.
Why it happens
Increased gastric pH from proton pump inhibition reduces rilpivirine dissolution and absorption.
What to do
Do not use together. Choose a different acid suppressant, such as an H2 blocker with timed separation, or an alternative antiretroviral.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Pantoprazole
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Pantoprazole with Rilpivirine?
MediHelp rates the interaction as contraindicated. Pantoprazole and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oral rilpivirine requires acidic gastric conditions for absorption, and pantoprazole markedly reduces its exposure. This can cause virologic failure and NNRTI resistance, and labeling contraindicates PPIs with oral rilpivirine.
How serious is the interaction between Pantoprazole and Rilpivirine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Choose a different acid suppressant, such as an H2 blocker with timed separation, or an alternative antiretroviral.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Acalabrutinib, Atazanavir, Dacomitinib. The full list is on the Pantoprazole page.
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