Drug interactions
Dabrafenib + Pazopanib
Severity: Moderate
Dabrafenib and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib is a CYP3A4 inducer and can lower pazopanib plasma concentrations. This may compromise pazopanib efficacy.
What this interaction means in plain words
Dabrafenib and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Pazopanib belongs to Oncology.
Why it happens
Dabrafenib induces CYP3A4, increasing pazopanib metabolism.
What to do
Monitor for reduced pazopanib effect and review whether the combination is needed. Avoid empirical pazopanib dose escalation without specialist guidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Pazopanib?
MediHelp rates the interaction as moderate. Dabrafenib and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib is a CYP3A4 inducer and can lower pazopanib plasma concentrations. This may compromise pazopanib efficacy.
How serious is the interaction between Dabrafenib and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced pazopanib effect and review whether the combination is needed. Avoid empirical pazopanib dose escalation without specialist guidance.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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