Drug interactions
Dabrafenib + Pimavanserin
Severity: Moderate
Dabrafenib and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib is a CYP3A4 inducer and may lower pimavanserin concentrations, which can reduce its effect on psychosis symptoms.
What this interaction means in plain words
Dabrafenib and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Pimavanserin belongs to Central Nervous System.
Why it happens
Dabrafenib induces CYP3A4, increasing pimavanserin metabolism.
What to do
Monitor for loss of pimavanserin efficacy and consider increasing the dose if needed. Reassess the dose if dabrafenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Pimavanserin?
MediHelp rates the interaction as moderate. Dabrafenib and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib is a CYP3A4 inducer and may lower pimavanserin concentrations, which can reduce its effect on psychosis symptoms.
How serious is the interaction between Dabrafenib and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of pimavanserin efficacy and consider increasing the dose if needed. Reassess the dose if dabrafenib is stopped.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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