Drug interactions
Dabrafenib + Praziquantel
Severity: Major
Dabrafenib and Praziquantel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib is a CYP3A4 inducer and may reduce praziquantel exposure. The antiparasitic effect may be diminished.
What this interaction means in plain words
Dabrafenib and Praziquantel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabrafenib belongs to Oncology; Praziquantel belongs to Anti Parasitic.
Why it happens
CYP3A4 induction by dabrafenib increases praziquantel metabolism.
What to do
Avoid combining where possible; consider timing praziquantel treatment with a dabrafenib interruption only if oncologically acceptable. Otherwise monitor response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Praziquantel?
MediHelp rates the interaction as major. Dabrafenib and Praziquantel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dabrafenib is a CYP3A4 inducer and may reduce praziquantel exposure. The antiparasitic effect may be diminished.
How serious is the interaction between Dabrafenib and Praziquantel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; consider timing praziquantel treatment with a dabrafenib interruption only if oncologically acceptable. Otherwise monitor response.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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