Drug interactions
Dabrafenib + Quinine
Severity: Moderate
Dabrafenib and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib is a CYP3A4 inducer and can lower quinine exposure, potentially reducing its efficacy in malaria. Dabrafenib may also prolong the QT interval, adding to the concern when combined with quinine.
What this interaction means in plain words
Dabrafenib and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Quinine belongs to Anti Parasitic.
Why it happens
Induction of CYP3A4 by dabrafenib increases quinine clearance.
What to do
Monitor for inadequate antimalarial response and consider an alternative agent if possible. Check ECG and electrolytes if both drugs are used given the QT effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dabrafenib and Quinine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Quinine?
MediHelp rates the interaction as moderate. Dabrafenib and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib is a CYP3A4 inducer and can lower quinine exposure, potentially reducing its efficacy in malaria. Dabrafenib may also prolong the QT interval, adding to the concern when combined with quinine.
How serious is the interaction between Dabrafenib and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for inadequate antimalarial response and consider an alternative agent if possible. Check ECG and electrolytes if both drugs are used given the QT effects.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
